A former saxophonist, Arthur Sampson “Art” Douglas and his family were killed by the Titanian Eternal Thanos while driving across the Mojave Desert. Kronos recovered Douglas’ astral form and used it to create a superhuman warrior for the purpose of defeating Thanos. After Thanos was defeated, Drax was eventually killed by a psychic attack from Moondragon.
Years later, Drax was resurrected to once again battle Thanos (also recently resurrected). Drax’s resurrection was not perfect, however; his brain remained damaged from his previous death. After Thanos was defeated a second time, Drax became a member of the Infinity Watch and guardian of the Power Gem.